[email protected]

The Frequency of Mutations in Exon 11 of the c-kit

Objective:To determine the frequency of mutations in exon 11 of the c-kit gene in patients with leukemia. Material and Methods:The study included 50 leukemia patients (31 with acute myeloid leukemia, 5 with acutelymphoblastic leukemia, 9 with chronic myeloid leukemia, and 5 with chronic lymphocytic leukemia) that underwentPCR-SSCP, followed by direct DNA sequencing. Differential eion of KIT/PDGFRA mutant isoforms in May 21, 2004 · Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior:KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors.

Gastrointestinal Stromal Tumors With KIT Exon 11 Deletions

Jan 31, 2006 · Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors. Clin Cancer Res. 2003; 9 :3329-3337 Gastrointestinal Stromal Tumors, Somatic Mutations and Apr 18, 2013 · Antonescu CR, Sommer G, Sarran L, Tschernyavsky SJ, Riedel E, et al. (2003) Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior:KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors. Clin Cancer Res.. 9:33293337. View Article Gastrointestinal stromal tumor:5 years later - van der Aug 31, 2005 · In contrast, patients with an exon 9 mutation had a 40% response rate and those without a kinase (KIT or PDGFRA) mutation were found to have a 39% response rate. Accordingly, patients with an exon 11 mutation had a significantly longer median time to treatment failure (576 days) compared with those with an exon 9 mutation (308 days) or no

KIT Gene Deletions at the Intron 10Exon 11 Boundary in GI

Nov 01, 2004 · Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior:KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors Clin Cancer Res , 9 ( 2003 ) , pp. 3329 - 3337 KIT gene mutation and amplification in dysgerminoma of the Nov 30, 2010 · The majority of KIT mutations are clustered in a relatively small region at exons 11 and 17, or less frequently, in KIT extracellular domain (exons 2, 8, and 9) or KIT TK1 (exons 13 and 14). 3, 4 Activating mutations typically confer constitutional KIT phosphorylation and downstream activation independent of ligand binding. Prognostic Indicators for Gastrointestinal Stromal Tumors Oct 01, 2020 · Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior:KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors Clin. Cancer Res. , 9 ( 2003 ) , pp. 3329 - 3337

Detection of a new mutation in KIT exon 9 in a

Nov 14, 2005 · Mutations consist of deletions, insertions, duplications or point mutations, all remaining in frame. 3, 4 They occur preferentially in exon 11 (67.5%), then exon 9 (11%) and more rarely in exons 13 (0.9%) and 17 (0.5%). 1, 5, 6, 7, 8 Tumor localization seems to correlate with the mutated exon, in particular for exon 9 mutations, which are mainly associated with a nongastric site. 9